Resverlogix's drug targets bromodomain proteins, which detect epigenetic modifications on histone proteins and recruits additional proteins to the site. As a result, the cells produce more Apo-A1, the main component of HDL, which helps remove atherosclerotic plaques already formed. "We think our drug will reverse the plaque buildup that causes hundreds of thousands of deaths each year," Donald McCaffrey, the president of Resverlogix told Nature.

David Fuller's view This tallies with what I have observed, experienced and mentioned in Comment of the Day. People who enjoy daily exercise are particularly prone to muscle ache caused by statins.

Also, if interested in this topic, read what The Scientist has to say about Epigenetic Drug Improves Cholesterol Levels. Here is a sample:


Resverlogix's drug targets bromodomain proteins, which detect epigenetic modifications on histone proteins and recruits additional proteins to the site. As a result, the cells produce more Apo-A1, the main component of HDL, which helps remove atherosclerotic plaques already formed. "We think our drug will reverse the plaque buildup that causes hundreds of thousands of deaths each year," Donald McCaffrey, the president of Resverlogix told Nature.

This is very promising, although as the medical email Comment below the article points out, "tweaking of immense gene networks" could easily have "unanticipated side effects that could be more important health considerations than raising HDL."