In this latest work, the researchers used a comprehensive set of assays to measure the expression of all genes in the brain, as well as over 500 small molecules involved with metabolism in the brains and blood of three groups of the rapidly aging mice. The three groups of rapidly aging mice included one set that was young, one set that was old and one set that was old but fed J147 as they aged.
?The old mice that received J147 performed better on memory and other tests for cognition and also displayed more robust motor movements. The mice treated with J147 also had fewer pathological signs of Alzheimer's in their brains. Importantly, because of the large amount of data collected on the three groups of mice, it was possible to demonstrate that many aspects of gene expression and metabolism in the old mice fed J147 were very similar to those of young animals. These included markers for increased energy metabolism, reduced brain inflammation and reduced levels of oxidized fatty acids in the brain.
Another notable effect was that J147 prevented the leakage of blood from the microvessels in the brains of old mice. “Damaged blood vessels are a common feature of aging in general, and in Alzheimer's, it is frequently much worse,” says Currais.
Currais and Schubert note that while these studies represent a new and exciting approach to Alzheimer’s drug discovery and animal testing in the context of aging, the only way to demonstrate the clinical relevance of the work is to move J147 into human clinical trials for Alzheimer’s disease.
“If proven safe and effective for Alzheimer’s, the apparent anti-aging effect of J147 would be a welcome benefit,” adds Schubert. The team aims to begin human trials next year.
Health systems in most Western countries are under increasing stress not because of drug use or alcoholism but because people are living longer with chronic conditions. Diseases like diabetes and conditions exacerbated by obesity are expensive to treat and incredibly time consuming. People living longer but with deteriorating mental and physical function, often with complications, represent major cost centres for health systems.
Pension systems are under enormous stress because people are living in retirement almost as long as they spent working and the numbers of new contributors to the system have been declining for years. What if people can not only live longer but are much healthier and have the vitality to continue to work for substantially longer? The economics of demographics would be completely upended and the modest growth forecasts espoused by many analysts would need to be updated.
The untouchable cost centres of most governments, health and pensions, are going to experience profound change over the next decades. However while the majority believe the consequences are going to be undeniably negative, there is the possibility that technological innovation will in fact represent an enormously bullish consideration for both.
Back to top